How NSAIDs cause glaucoma

Q.2.

steroid induced glaucoma is a form of open-angle glaucoma. the exact mechanism by which intake of NSAIDS induces Increased Ocular Pressure is not known. several theories have been put foward to explain the phenomenon.

1. They cause release of adhesive substances such as fibronectin that causes clogging in the trabecular mesh resulting in reduced outflow of aqueous fluid- thus increased IOP
2. they limit the phagocytic activity of the endothelial cells lining the trabecular mesh leading to accumulation of aqueous debris that end up clogging the trabecular mesh.
3. In instances of intraocular administration of NSAIDs (eg intravitreal triamcinolone acetonide IVTA used in diabetic macular edema) , crystalline particles of the drug may form at the trabecular mesh
4. They reduce the production of prostaglandins which have a role in regulation of aqueous outflow.