alkylaing agents


ALKYLATING AGENTS

These drugs act by covalently binding alkyl groups found on the DNA strands. This results in cross-link the DNA strands interfering with DNA synthesis. They are among the earliest cytotoxic agents to be discovered in the early 20th century, and still hold a central key position in the treatment of cancer. Common drugs in this class are
  •           Cyclophosphamide
  •           Chlorambucil
  •           Busulphan
  •           Mustine hydrochloride (HN2)
  •           Melphalan
  •           Nitrosoureas (eg Lomustine)
  •           Ifosfamide
  •           Treosulfan


SIDEEFFECTS OF ALKYLATING AGENTS


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