alkylaing agents

ALKYLATING AGENTS

These drugs act by covalently binding alkyl groups found on the DNA strands. This results in cross-link the DNA strands interfering with DNA synthesis. They are among the earliest cytotoxic agents to be discovered in the early 20^th century, and still hold a central key position in the treatment of cancer. Common drugs in this class are

•           Cyclophosphamide
•           Chlorambucil
•           Busulphan
•           Mustine hydrochloride (HN2)
•           Melphalan
•           Nitrosoureas (eg Lomustine)
•           Ifosfamide
•           Treosulfan

SIDEEFFECTS OF ALKYLATING AGENTS

cytotoxic agents, leukemia,