QUINOLONES AND FLUOROQUINOLONES ANTIBACTERIALS
These drugs
interfere with DNA replication and transcription in bacteria by binding to
bacterial DNA gyrase that’s needed in the final stages of DNA replication. This
interference destructs cell processes leading to bacterial death. These drugs are therefore considered
bacteriosidal.
Used to treat
genitourinary tract infection and limited to other severe cases where multidrug
resistance is most like to occur.
Examples include
Ø ciprofloxacin (Cipro)
Ø levofloxacin (Levaquin/Quixin)
Ø gatifloxacin (Tequin)
Ø moxifloxacin (Avelox)
Ø ofloxacin (Ocuflox/Floxin/Floxacin)
Ø norfloxacin
metabolism- liver
Elimination- renal
Pregnancy category- C
Side effects
Fluoroquinolones
are generally very safe antibiotics which do not cause serious or
life-threatening adverse reactions. The most frequent side-effects are
gastrointestinal reactions (nausea, dyspepsia, vomiting) and CNS reactions such
as dizziness, insomnia and headache.
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