TETRACYCLINES

TETRACYCLINE ANTIBACTERIALS

Tetracyclines  is a broad spectrum antibiotic that binds to the bacterial 30S ribosome, blocking the entry of transfer RNA. This ultimately prevents protein synthesis and thus inhibiting bacterial growth. They are therefore described as bacteriostatic.

 Examples include ; tetracycline, doxycycline, oxytetracycline, lymecycline, minocycline

Metabolism- liver

Excreation – kidney

Pregnancy category- D (teratogenic)

Side effects

-          Phototoxicity

-          Increases risk for Sun burns

-          GI disturbances

-          Severe headache and intracranial hypertension

-          Fetal bone/teeth discoloration

QUINOLONES/FLUOROQUINOLONES

para-cervical block, leukemia, complete blood count, beta lactams